The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Nov. 06, 2008
Donghui Qin, Collegeville, PA (US);
Beth Norton, Research Triangle Park, NC (US);
Andrew Nicholas Knox, Collegeville, PA (US);
Siegfried B. Christensen, Collegeville, PA (US);
Kelly M. Aubart, Collegeville, PA (US);
Donghui Qin, Collegeville, PA (US);
Beth Norton, Research Triangle Park, NC (US);
Andrew Nicholas Knox, Collegeville, PA (US);
Siegfried B. Christensen, Collegeville, PA (US);
Kelly M. Aubart, Collegeville, PA (US);
GlaxoSmithKline LLC, Philadelphia, PA (US);
Abstract
The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.