The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Jul. 30, 2007
Giancarlo Tonon, Pula, IT;
Gaetano Orsini, Gallarate, IT;
Rodolfo Schrepfer, Villa Guardia, IT;
Geoffrey Taylor, Pula, IT;
Mauro Sergi, Padua, IT;
Giancarlo Tonon, Pula, IT;
Gaetano Orsini, Gallarate, IT;
Rodolfo Schrepfer, Villa Guardia, IT;
Geoffrey Taylor, Pula, IT;
Mauro Sergi, Padua, IT;
Bio-Ker S.r.l., , IT;
Abstract
Novel site-specific mono-conjugates of Granulocyte Colony Stimulating Factor (G-CSF) are hereby described, with analogues and derivatives thereof, which stimulate proliferation and differentiation of progenitor cells to mature neutrophiles. These conjugates have been obtained using transglutaminase to covalently and site-specifically bind a hydrophilic, non-immunogenic polymer to a single glutamine residue of the human G-CSF native sequence and analogues thereof. These novel site-specific mono-conjugated derivatives are recommended for therapeutic use since they are stable in solution and exhibit significant biological activity in vitro and a longer bloodstream half-life, as compared to the non-conjugated protein, with a consequent prolonged pharmacological activity.