The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Jul. 07, 2008
Applicants:
Philip J. Barr, Oakland, CA (US);
Helen L. Gibson, Oakland, CA (US);
Inventors:
Philip J. Barr, Oakland, CA (US);
Helen L. Gibson, Oakland, CA (US);
Assignee:
Arriva Pharmaceuticals, Inc., Alameda, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C12N 1/00 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
Abstract
Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, and where the polynucleotide contains one or more yeast-preferred codons. Host cells are cultured under conditions where, after an initial batch phase, oxygen concentration is kept high and glucose feed is regulated so that the yeast cells stay in respiratory metabolism.