The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Feb. 15, 2008
Rajakkannu Mutharasan, West Chester, PA (US);
David R. Maraldo, Gilbertsville, PA (US);
Kishan Rijal, Harleysville, PA (US);
Gossett Augustus Campbell, Gilbertsville, PA (US);
Paul Karl Horan, Kennett Square, PA (US);
Rajakkannu Mutharasan, West Chester, PA (US);
David R. Maraldo, Gilbertsville, PA (US);
Kishan Rijal, Harleysville, PA (US);
Gossett Augustus Campbell, Gilbertsville, PA (US);
Paul Karl Horan, Kennett Square, PA (US);
Drexel University, Philadelphia, PA (US);
Leversense, LLC, Newtown Square, PA (US);
Abstract
Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is exposed to the analyte. The analyte binds to the antibody. The sensor then is exposed to additional antibody, which binds to the analyte. The sensor then can be sequentially exposed to additional antibodies that are known to bind to previously bound antibodies. Each additional binding further increases the effective mass of accumulated material on the sensor. The total effective mass is greater than the mass of the accumulated analyte, thus providing means for detecting extremely minute amounts of analyte. Applications include detection of pathogens and DNA.