The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Nov. 21, 2006
Yan Yeung Luk, Manlius, NY (US);
Karen A. Simon, Syracuse, NY (US);
Erik A. Burton, Phoenix, NY (US);
Prerli Sejwal, Syracuse, NY (US);
Yongbin Han, Syracuse, NY (US);
Yan Yeung Luk, Manlius, NY (US);
Karen A. Simon, Syracuse, NY (US);
Erik A. Burton, Phoenix, NY (US);
Prerli Sejwal, Syracuse, NY (US);
YongBin Han, Syracuse, NY (US);
Syracuse University, Syracuse, NY (US);
Abstract
A system and method for using gradient nanotopography to increase mammalian cell attachment and cell confinement on surfaces. A surface platform consisting of a thin film of gold possessing a gradient of topography on the surface and self-assembled monolayers of alkanethiols presenting desired functional groups is formed. A gradient in the chemical properties is induced in the terminal groups of the monolayer because of the continuous increase in the surface area and the anisotropy of gold film structure. The gradient nanotopraphy provides simultaneous control of two key properties, the presentation of the terminal functional groups and a continuous increase in the surface density of functional groups on the surface. This control provides for drug screening assays using adherent cell-based experiments.