The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2011
Filed:
Mar. 31, 2009
Michele Sanicola-nadel, Winchester, MA (US);
Kevin P. Williams, Natick, MA (US);
Susan Gail Schiffer, Lexington, MA (US);
Paul Rayhorn, Foxboro, MA (US);
Michele Sanicola-Nadel, Winchester, MA (US);
Kevin P. Williams, Natick, MA (US);
Susan Gail Schiffer, Lexington, MA (US);
Paul Rayhorn, Foxboro, MA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.