The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2011
Filed:
Oct. 09, 2006
Michael C. Kiefer, Clayton, CA (US);
Paul A. Fitzpatrick, Albany, CA (US);
Helen L. Gibson, Oakland, CA (US);
Philip J. Barr, Oakland, CA (US);
Michael C. Kiefer, Clayton, CA (US);
Paul A. Fitzpatrick, Albany, CA (US);
Helen L. Gibson, Oakland, CA (US);
Philip J. Barr, Oakland, CA (US);
Genetech, Inc., South San Francisco, CA (US);
Abstract
The present invention provide polynucleotide sequences encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provide recombinant host cells containing polynucleotides encoding BBP. The invention further provide antibodies that specifically bind to BBP. The invention further provide methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provide methods for detecting the presence of Bak polynucleotides and the encoding proteins in a biological sample, and further provide methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the 'BBP Binding Domains' and the respective nucleotides, designated 'bbpbd-1' and “bbpbd-2” which are involved in the interaction between Bak and BBP.