The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2011
Filed:
Dec. 04, 2002
Eliahu Heldman, Rehovot, IL;
Charles Linder, Rehovot, IL;
Sarina Grinberg, Meitar, IL;
Victoria Kolot, Beer-Sheva, IL;
Eleonora Shaubi, Beer-Sheva, IL;
Eliahu Heldman, Rehovot, IL;
Charles Linder, Rehovot, IL;
Sarina Grinberg, Meitar, IL;
Victoria Kolot, Beer-Sheva, IL;
Eleonora Shaubi, Beer-Sheva, IL;
Abstract
An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.