The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2011
Filed:
Feb. 29, 2008
Mikkel Wandahl Pedersen, Alleroed, DK;
Lucilla Steinaa, Hoersholm, DK;
Allan Jensen, Fredensborg, DK;
Klaus Koefoed, Copenhagen S, DK;
Per-johan Meijer, Copenhangen N, DK;
Robert Carlsson, Malmoe, SE;
Charles Pyke, Hilleroed, DK;
Lars S. Nielsen, Nivaa, DK;
Mikkel Wandahl Pedersen, Alleroed, DK;
Lucilla Steinaa, Hoersholm, DK;
Allan Jensen, Fredensborg, DK;
Klaus Koefoed, Copenhagen S, DK;
Per-Johan Meijer, Copenhangen N, DK;
Robert Carlsson, Malmoe, SE;
Charles Pyke, Hilleroed, DK;
Lars S. Nielsen, Nivaa, DK;
Symphogen A/S, Lyngby, DK;
Abstract
The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies showed synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.