The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2011
Filed:
Jul. 02, 2007
Michele L. R. Heffernan, Worcester, MA (US);
Robert J. Foglesong, Durham, NC (US);
Seth C. Hopkins, Clinton, MA (US);
Mustapha Soukri, Raleigh, NC (US);
Steven W. Jones, Milford, MA (US);
Kerry L. Spear, Concord, MA (US);
Mark A. Varney, Laguna Niguel, CA (US);
Michele L. R. Heffernan, Worcester, MA (US);
Robert J. Foglesong, Durham, NC (US);
Seth C. Hopkins, Clinton, MA (US);
Mustapha Soukri, Raleigh, NC (US);
Steven W. Jones, Milford, MA (US);
Kerry L. Spear, Concord, MA (US);
Mark A. Varney, Laguna Niguel, CA (US);
Sepracor Inc., Marlborough, MA (US);
Abstract
This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CRand N. X and Y are members independently selected from O, S, CR, N and NH. R, Rand Rare members independently selected from H and F, provided that at least one member selected from R, Rand Ris F. Ris a member selected from OXand OH, wherein Xis a positive ion, which is a member selected from inorganic positive ions and organic positive ions.