The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2011
Filed:
May. 12, 2005
Larry R. Brown, Newton, MA (US);
Vered Bisker-leib, Woburn, MA (US);
Terrence L. Scott, Winchester, MA (US);
Debra Lafreniere, Dighton, MA (US);
Jennifer Machen, Export, PA (US);
Nick Giannoukakls, Coraopolis, PA (US);
Larry R. Brown, Newton, MA (US);
Vered Bisker-Leib, Woburn, MA (US);
Terrence L. Scott, Winchester, MA (US);
Debra Lafreniere, Dighton, MA (US);
Jennifer Machen, Export, PA (US);
Nick Giannoukakls, Coraopolis, PA (US);
Baxter International Inc., Deerfield, IL (US);
Baxter Healthcare S.A., Glattpark (Opfikon), CH;
University of Pittsburgh-of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.