The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 08, 2011

Filed:

May. 12, 2005
Applicants:

Larry R. Brown, Newton, MA (US);

Vered Bisker-leib, Woburn, MA (US);

Terrence L. Scott, Winchester, MA (US);

Debra Lafreniere, Dighton, MA (US);

Jennifer Machen, Export, PA (US);

Nick Giannoukakls, Coraopolis, PA (US);

Inventors:

Larry R. Brown, Newton, MA (US);

Vered Bisker-Leib, Woburn, MA (US);

Terrence L. Scott, Winchester, MA (US);

Debra Lafreniere, Dighton, MA (US);

Jennifer Machen, Export, PA (US);

Nick Giannoukakls, Coraopolis, PA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); C07H 21/04 (2006.01); A61K 9/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.


Find Patent Forward Citations

Brown, Larry. (2011). Delivery of as-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes (U.S. Patent No. 7884085). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7884085

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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