The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2011
Filed:
Apr. 01, 2003
Stewart Cole, Clamart, FR;
Alexander S. Pym, London, GB;
Roland Brosch, Paris, FR;
Priscille Brodin, Paris, FR;
Laleh Majlessi, Montigny le Bretonneux, FR;
Caroline Demangel, Paris, FR;
Claude Leclerc, Paris, FR;
Stewart Cole, Clamart, FR;
Alexander S. Pym, London, GB;
Roland Brosch, Paris, FR;
Priscille Brodin, Paris, FR;
Laleh Majlessi, Montigny le Bretonneux, FR;
Caroline Demangel, Paris, FR;
Claude Leclerc, Paris, FR;
Institut Pasteur, Paris, FR;
Abstract
The present invention relates to a strain ofBCG or, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as theBCG::RDI or::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer. These strains are also useful for the expression and presentation of heterologous antigens and molecule that are of therapeutic or prophylactic interest.