The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2011
Filed:
Jun. 29, 2007
Sankar Reddy Budidet, Hyderabad, IN;
Senthil Kumar Natarajan, Hyderabad, IN;
Venkata Kishore Gowrabathina, Hyderabad, IN;
Ramesh Dandala, Hyderabad, IN;
Sivakumaran Meenakshisunderam, Hyderabad, IN;
Sankar Reddy Budidet, Hyderabad, IN;
Senthil Kumar Natarajan, Hyderabad, IN;
Venkata Kishore Gowrabathina, Hyderabad, IN;
Ramesh Dandala, Hyderabad, IN;
Sivakumaran Meenakshisunderam, Hyderabad, IN;
Aurobindo Pharma Ltd., Hyderabad, IN;
Abstract
The present invention provides a method for the preparation of N-(1-oxopentyl)-N-[[2'-(1H-tetra-zol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine (Valsartan) which comprises; treating N-[[2′-(1-triphenylmethyl-tetra-zol-5-yl)biphenyl-4-yl]methyl]-L-valine methyl ester (X) with oxalic acid or its hydrates in a solvent to produce N-[[2′-(1-triph-enylmethyl-tetrazol-5-yl)biphenyl-4-yl]methy]-L-valine methyl ester oxalate (Xa) and treating the compound (Xa) with a base in a solvent followed by reacting with valeryl chloride in presence of base in a solvent to produce N-[[2′-(1-triphenylmethyl-tetra-zol-5-yl)[1,1′biphenyl]-4-yl]methyl]-N-valeryl-L-valine methyl ester (XI), de-protecting the compound (XI) using anhydrous acidic conditions to produce N-(1-oxopentyl)-N-[[2′-(1-H-tetrazol-5-yl)[1,1′biphenyl]-4-yl]methyl-L-valine methyl ester (V) followed by treating with base in a solvent to produce Valsartan.