The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2011
Filed:
Sep. 13, 2002
Helle Birk Olsen, Allerod, DK;
Niels C. Kaarsholm, Vanlose, DK;
Peter Madsen, Bagsvaerd, DK;
Soren Ostergaard, Bronshoj, DK;
Svend Ludvigsen, Lyuge, DK;
Palle Jakobsen, Vaerlose, DK;
Anders Klarskov Petersen, Naerum, DK;
Dorte Bjerre Steensgaard, Copenhagen, DK;
Helle Birk Olsen, Allerod, DK;
Niels C. Kaarsholm, Vanlose, DK;
Peter Madsen, Bagsvaerd, DK;
Soren Ostergaard, Bronshoj, DK;
Svend Ludvigsen, Lyuge, DK;
Palle Jakobsen, Vaerlose, DK;
Anders Klarskov Petersen, Naerum, DK;
Dorte Bjerre Steensgaard, Copenhagen, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The present invention relates to novel ligands for the HisZnsites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisZnsites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NHor a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.