The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2011
Filed:
Mar. 23, 2005
Steven A. Boyd, Longmont, CO (US);
Kevin R. Condroski, Broomfield, CO (US);
Allen Thomas, Louisville, CO (US);
Stephen S. Gonzales, Media, PA (US);
Indrani W. Gunawardana, Longmont, CO (US);
Yvan Le Huerou, Boulder, CO (US);
Todd T. Romoff, Firestone, CO (US);
Francis X. Sullivan, Boulder, CO (US);
Steven A. Boyd, Longmont, CO (US);
Kevin R. Condroski, Broomfield, CO (US);
Allen Thomas, Louisville, CO (US);
Stephen S. Gonzales, Media, PA (US);
Indrani W. Gunawardana, Longmont, CO (US);
Yvan Le Huerou, Boulder, CO (US);
Todd T. Romoff, Firestone, CO (US);
Francis X. Sullivan, Boulder, CO (US);
Array Biopharma, Inc., Boulder, CO (US);
Abstract
The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R, R, R, R, R, R, R-R, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.