The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2011
Filed:
Jun. 16, 2008
Steven Foung, Stanford, CA (US);
Zhen-yong Keck, Redwood City, CA (US);
Richard Webby, Memphis, TN (US);
Steven Foung, Stanford, CA (US);
Zhen-Yong Keck, Redwood City, CA (US);
Richard Webby, Memphis, TN (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
Abstract
A panel of IgGhuman monoclonal antibodies (HMAbs) identified by hemagglutination inhibition (HI) assay has been produced from peripheral B cells of an individual immunized with prototype H5N1 vaccine. Sequence analysis of antibody clones showed three clusters of different HMAbs as represented by HMAbs designated as BF1-1, BF1-19 and BF1-10. BF1-1 and BF1-10 have distinct CDR 1, 2 and 3 regions of both heavy and light chains. BF1-19 has the same heavy chain as BF1-1 but the light chain of BF1-10. Antibody binding affinity, K, studies showed all three HMAbs ranging from at least about 10to at least about 10. In vivo protection studies showed that these antibodies afforded significant protection against infection. These findings demonstrate that the antibodies of the invention are cross-neutralizing and therapeutic.