The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2011
Filed:
Oct. 10, 2008
Michaela Kneissel, Basel, CH;
Christine Halleux, Dornach, CH;
Shou-ih HU, New Providence, NJ (US);
Beate Diefenbach-streiber, Windach, DE;
Josef Prassler, Germering, DE;
Michaela Kneissel, Basel, CH;
Christine Halleux, Dornach, CH;
Shou-Ih Hu, New Providence, NJ (US);
Beate Diefenbach-Streiber, Windach, DE;
Josef Prassler, Germering, DE;
Novartis AG, Basel, CH;
Abstract
The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.