The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2011
Filed:
May. 14, 2009
Michael C. Heinrich, Lake Oswego, OR (US);
Christopher C. Corless, Portland, OR (US);
Jonathan A. Fletcher, Brookline, MA (US);
George D. Demetri, Brookline, MA (US);
Michael C. Heinrich, Lake Oswego, OR (US);
Christopher C. Corless, Portland, OR (US);
Jonathan A. Fletcher, Brookline, MA (US);
George D. Demetri, Brookline, MA (US);
Oregon Health & Science University, Portland, OR (US);
The United States of America as represented by the Department of Veterans Affairs, Washington, DC (US);
Dana-Faber Cancer Institute, Boston, MA (US);
Brigham and Women's Hospital, Boston, MA (US);
Abstract
This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.