The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2011
Filed:
Jan. 31, 2005
Yung-chi Cheng, Woodbridge, CT (US);
Yashang Lee, New Haven, CT (US);
Hosup Yeo, Daegu, KR;
Yale University, New Haven, CT (US);
Abstract
The present invention is directed to analogs of baicalein according to formula (I): where Ris H, (C-C)alkyl, (C-C)acyl, or an optionally substituted phenyl or benzyl group, an acyl group, a C-Calkyl or ether group, a phosphate, diphosphate, triphosphate or phosphodiester group; Rand Rare each independently H, (C-C)alkyl, (C-C)acyl, or an optionally substituted phenyl or benzyl or together form a —OCRRO— group wherein each of Rand Ris independently H, a C-Calkyl group or an optionally substituted phenyl or benzyl group; and Ris H, OH, an O-acyl group, a C,-Calkyl or alkoxy group, F, Cl, Br or I, or a pharmaceutically acceptable salt thereof, which exhibit anti-P-glycoprotein activity and methods of enhancing the bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme, especially CYP450 3A4 enzyme. Pharmaceutical compositions based upon these novel derivatives according to the present invention are also described herein.