The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2011
Filed:
Sep. 30, 2008
Robert W. Bryant, Princeton, NJ (US);
S. Paul Lee, Yardley, PA (US);
Rok Cerne, Lawrenceville, NJ (US);
M. N. Tulu Buber, Newtown, PA (US);
Ivona Bakaj, Cranbury, NJ (US);
Roy Kyle Palmer, Cranbury, NJ (US);
Robert W. Bryant, Princeton, NJ (US);
S. Paul Lee, Yardley, PA (US);
Rok Cerne, Lawrenceville, NJ (US);
M. N. Tulu Buber, Newtown, PA (US);
Ivona Bakaj, Cranbury, NJ (US);
Roy Kyle Palmer, Cranbury, NJ (US);
Redpoint Bio Corporation, Ewing, NJ (US);
Abstract
There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.