The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 18, 2011
Filed:
Sep. 22, 2006
Donald P Bottaro, Kensington, MD (US);
Alessio Giubellino, Bethesda, MD (US);
Safiye N Atabey, Alsancak, TR;
Jesus V Soriano, Washington, DC (US);
Diane E Breckenridge, Bethesda, MD (US);
Terrence R Burke, Jr., Bethesda, MD (US);
Donald P Bottaro, Kensington, MD (US);
Alessio Giubellino, Bethesda, MD (US);
Safiye N Atabey, Alsancak, TR;
Jesus V Soriano, Washington, DC (US);
Diane E Breckenridge, Bethesda, MD (US);
Terrence R Burke, Jr., Bethesda, MD (US);
Abstract
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. Also disclosed are methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer, for example, melanoma or prostate cancer, comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking blocks HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.