The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Jun. 01, 2006
Klaus Hellmuth, Berlin, DE;
Walter Birchmeier, Schwanebeck, DE;
Joerg Rademann, Berlin, DE;
Stefanie Grosskopf, Berlin, DE;
Klaus Hellmuth, Berlin, DE;
Walter Birchmeier, Schwanebeck, DE;
Joerg Rademann, Berlin, DE;
Stefanie Grosskopf, Berlin, DE;
Max-Delbruck-Centrum fur Molekulare Medizin, Berlin, DE;
Forschungsverbund Berlin E, V., Berlin, DE;
Abstract
The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formula (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated diseases, especially cancer and metastasis. The invention further concerns a method for treating a proliferative disease, a genetic disorder, an autoimmune disease, an angiogenic disorder or cancer in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of at least one compound of formula (I) and/or (II).