The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Sep. 20, 2006
Miroslav Veverka, Bratislava, SK;
Martin Putala, Bratislava, SK;
Heinrich Brath, Hostova, SK;
Silvo Zuppancic, Novo Mesto, SI;
Miroslav Veverka, Bratislava, SK;
Martin Putala, Bratislava, SK;
Heinrich Brath, Hostova, SK;
Silvo Zuppancic, Novo Mesto, SI;
KRKA, d.d. Novo mesto, Novo Mesto, SI;
Abstract
The invention provides a process for the preparation of a sartan derivative of formula (I) (formula as filed in paper form) (I) wherein the substituents have the meaning indicated in the description, or a pharmaceutically acceptable salt thereof, comprising reacting 2-cyanophenylboronic acid or a derivative thereof with a p-halobenzyl-1H-imidazole derivative of formula (VI), (formula as filed in paper form) (VI) wherein (part of formula as filed in paper form), X, Y, Rand Rare as defined above, and Z is I, Br or Cl, in the presence of a transition metal catalyst and an inorganic or organic base. The invention also provides new intermediates of formula (V), (formula as filed in paper form) (V) wherein M is an alkali metal or an NRRRRgroup; and of formula (II) (formula as filed in paper form) (II).