The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Feb. 21, 2007
Victor J. Cee, Thousand Oaks, CA (US);
Holly L. Deak, Brookline, MA (US);
Stephanie D. Geuns-meyer, Medford, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Hanh Nho Nguyen, Arlington, MA (US);
Philip R. Olivieri, Medford, MA (US);
Vinod F. Patel, Acton, MA (US);
Karina Romero, Cambridge, MA (US);
Victor J. Cee, Thousand Oaks, CA (US);
Holly L. Deak, Brookline, MA (US);
Stephanie D. Geuns-Meyer, Medford, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Hanh Nho Nguyen, Arlington, MA (US);
Philip R. Olivieri, Medford, MA (US);
Vinod F. Patel, Acton, MA (US);
Karina Romero, Cambridge, MA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to chemical compounds having a general formula I wherein A, B, C, C, D, L, Land Rare defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.