The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Apr. 28, 2006
Giovanna Basile, Genoa, IT;
Umberto Benatti, Genoa, IT;
Santina Bruzzone, Genoa, IT;
Gianluca Damonte, Arenzano, IT;
Antonio DE Flora, Genoa, IT;
Ernesto Fattorusso, Naples, IT;
Luisa Franco, Genoa, IT;
Lucrezia Guida, Genoa, IT;
Orazio Taglialatela-scafati, Acerra, IT;
Elena Zocchi, Genoa, IT;
Giovanna Basile, Genoa, IT;
Umberto Benatti, Genoa, IT;
Santina Bruzzone, Genoa, IT;
Gianluca Damonte, Arenzano, IT;
Antonio De Flora, Genoa, IT;
Ernesto Fattorusso, Naples, IT;
Luisa Franco, Genoa, IT;
Lucrezia Guida, Genoa, IT;
Orazio Taglialatela-Scafati, Acerra, IT;
Elena Zocchi, Genoa, IT;
Universita' Degli Studi Di Genova, Genoa, IT;
Centro Biotecnologie Avanzate, Genoa, IT;
Abstract
The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD.