The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Aug. 23, 2006
Applicants:
Hong Zhao, Edison, NJ (US);
Belen Rubio, Somerset, NJ (US);
Jing Xia, Warren, NJ (US);
Inventors:
Assignee:
Enzon Pharmaceuticals, Inc., Bridgewater, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08G 79/02 (2006.01); C08G 79/08 (2006.01); C08G 73/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.