The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Feb. 22, 2005
Peter Nilsson, Linkoping, SE;
Anna Herland, Linkoping, SE;
Per Hammarstrom, Linkoping, SE;
Peter Asberg, Linkoping, SE;
Olle Inganas, Linkoping, SE;
Peter Nilsson, Linkoping, SE;
Anna Herland, Linkoping, SE;
Per Hammarstrom, Linkoping, SE;
Peter Asberg, Linkoping, SE;
Olle Inganas, Linkoping, SE;
BioChromix AB, Linkoping, SE;
Abstract
The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.