The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2011
Filed:
Mar. 29, 2007
James M. Balkovec, Martinsville, NJ (US);
Frances Aileen Bouffard, Scotch Plains, NJ (US);
Bruno Tse, San Diego, CA (US);
James Dropinski, Colts Neck, NJ (US);
Dongfang Meng, Westfield, NJ (US);
Mark L. Greenlee, Plainfield, NJ (US);
Michael Peel, Chapel Hill, NC (US);
Weiming Fan, Chapel Hill, NC (US);
Ahmed Mamai, Raleigh, NC (US);
Hao Liu, Raleigh, NC (US);
Keqaing LI, Cary, NC (US);
James M. Balkovec, Martinsville, NJ (US);
Frances Aileen Bouffard, Scotch Plains, NJ (US);
Bruno Tse, San Diego, CA (US);
James Dropinski, Colts Neck, NJ (US);
Dongfang Meng, Westfield, NJ (US);
Mark L. Greenlee, Plainfield, NJ (US);
Michael Peel, Chapel Hill, NC (US);
Weiming Fan, Chapel Hill, NC (US);
Ahmed Mamai, Raleigh, NC (US);
Hao Liu, Raleigh, NC (US);
Keqaing Li, Cary, NC (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Scynexis, Inc., Research Triangle Park, NC (US);
Abstract
The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.