The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2011
Filed:
Feb. 23, 2005
Mitsuo Sekine, Yokohama, JP;
Kohji Seio, Yokohama, JP;
Masahiro Mizuta, Yokohama, JP;
Takeshi Terada, Yokohama, JP;
Mitsuo Sekine, Yokohama, JP;
Kohji Seio, Yokohama, JP;
Masahiro Mizuta, Yokohama, JP;
Takeshi Terada, Yokohama, JP;
Japan Science and Technology Agency, Kawaguchi-shi Saitama, JP;
Abstract
The purpose of the present invention is to provide a compound that specifically binds to the base sequence of a double-stranded nucleic acid molecule. The compound can reduce the electrochemical signal/noise ratio (S/N) in electrochemical detection, and as a result, the detection sensitivity (precision) will be greatly improved so as to enable the determination of an ultratrace amount of nucleic acid molecule. The present invention relates to a ferrocene compound represented by the following general formula (I): wherein 'A' represents a divalent ferrocene-containing linker or ferrocene-1,1'-yl, Rrepresents a hydrogen atom or alkyl; 'n' and “m” represent any natural numbers; and “V” and “X” represent the pyrrole-imidazole-polyamide (PIPA); to a ligand consisting of said ferrocene compound for sequence-specific detection of double-stranded nucleic acid molecules; to a method for electrochemical detection of double-stranded nucleic acid molecules 8 with the use of said ligand; and to an apparatus or device for the electrochemical detection with the use of said ligand.