The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2011
Filed:
Nov. 16, 2005
Robert R. Redfield, Baltimore, MD (US);
Anthony Amoroso, Baltimore, MD (US);
Charles E. Davis, Laurel, MD (US);
Alonso Heredia, Washington, DC (US);
Robert R. Redfield, Baltimore, MD (US);
Anthony Amoroso, Baltimore, MD (US);
Charles E. Davis, Laurel, MD (US);
Alonso Heredia, Washington, DC (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Abstract
The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.