The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2011
Filed:
Jun. 18, 2004
Masayuki Tsuchiya, Shizuoka, JP;
Shigeyuki Iijima, Shizuoka, JP;
Izumi Sugo, Shizuoka, JP;
Yasuo Sekimori, Shizuoka, JP;
Kenju Ueno, Shizuoka, JP;
Kiyoshi Habu, Ibaraki, JP;
Masayuki Tsuchiya, Shizuoka, JP;
Shigeyuki Iijima, Shizuoka, JP;
Izumi Sugo, Shizuoka, JP;
Yasuo Sekimori, Shizuoka, JP;
Kenju Ueno, Shizuoka, JP;
Kiyoshi Habu, Ibaraki, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The present invention provides a gene encoding a fucose transporter, a fucose transporter polypeptide, a method for screening for a compound that binds to a fucose transporter or a compound that inhibits fucose transport activity, a cell having inhibited fucose transporter functions, and a cell wherein the expression of the fucose transporter is inhibited. The present invention further relates to a method for producing recombinant protein, and specifically, to a method for producing protein by which fucose existing within the Golgi apparatus of a host cell is decreased, a method for inhibiting the addition of fucose to protein by which fucose existing within the Golgi apparatus of a host cell is decreased upon production of recombinant protein using the host cell, a method for increasing the cytotoxic activity of an antibody by which an antibody is produced using a cell wherein fucose existing within the Golgi apparatus is decreased, and a cell having a Golgi apparatus wherein fucose existing within the Golgi apparatus is decreased.