The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Nov. 24, 2009
Applicants:
Claudio Soto-jara, Friendswood, TX (US);
Claudia Pena-rossi, Geneva, CH;
Inventors:
Claudio Soto-Jara, Friendswood, TX (US);
Claudia Pena-Rossi, Geneva, CH;
Assignee:
Merck Serono SA, Coinsins, Vaud, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 5/07 (2010.01); C12N 15/00 (2006.01); C12P 21/02 (2006.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with natural OX40L for blocking OX40R-mediated cell signaling in the prophylaxis and/or treatment of diseases related to activated T cells.