The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Jun. 21, 2005
Jaeheon Lee, Kyungki-do, KR;
Gha-seung Park, Kyungki-do, KR;
Moonsub Lee, Daejeon, KR;
Han Kyong Kim, Kyungki-do, KR;
Hyo-jeong Bang, Kyungki-do, KR;
Young-kil Chang, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Jaeheon Lee, Kyungki-do, KR;
Gha-Seung Park, Kyungki-do, KR;
Moonsub Lee, Daejeon, KR;
Han Kyong Kim, Kyungki-do, KR;
Hyo-Jeong Bang, Kyungki-do, KR;
Young-Kil Chang, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Hanmi Pharm. Co., Ltd, Kyungki-Do, KR;
Abstract
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple procedure such as recrystallization, and therefore, it can be advantageously used as an intermediate in the preparation of gemcitabine in a large scale. Further, the 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) can be prepared with high stereoselectivity using the compound of formula (V) as an intermediate.