The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Oct. 06, 2008
Cameron S. Brandt, Seattle, WA (US);
Jacob J. Kennedy, Seattle, WA (US);
Wenfeng Xu, Seattle, WA (US);
Eugene C. Yi, Mill Creek, WA (US);
Brian A. Fox, Seattle, WA (US);
Zeren Gao, Redmond, WA (US);
Cameron S. Brandt, Seattle, WA (US);
Jacob J. Kennedy, Seattle, WA (US);
Wenfeng Xu, Seattle, WA (US);
Eugene C. Yi, Mill Creek, WA (US);
Brian A. Fox, Seattle, WA (US);
Zeren Gao, Redmond, WA (US);
ZymoGenetics, Inc., Seattle, WA (US);
Abstract
Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.