The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
May. 05, 2009
Anthony Frank Kreft, Langhorne, PA (US);
Lynn Resnick, Parlin, NJ (US);
Scott Christian Mayer, Bridgewater, NJ (US);
George Diamantidis, Randolph, NJ (US);
Derek Cecil Cole, New City, NY (US);
Boyd Lynn Harrison, Princeton Junction, NJ (US);
Minsheng Zhang, Warren, NJ (US);
Molly Hoke, Hightstown, NJ (US);
Tingzhong Wang, Pomona, NY (US);
Rocco John Galante, Oakland, NJ (US);
Anthony Frank Kreft, Langhorne, PA (US);
Lynn Resnick, Parlin, NJ (US);
Scott Christian Mayer, Bridgewater, NJ (US);
George Diamantidis, Randolph, NJ (US);
Derek Cecil Cole, New City, NY (US);
Boyd Lynn Harrison, Princeton Junction, NJ (US);
Minsheng Zhang, Warren, NJ (US);
Molly Hoke, Hightstown, NJ (US);
Tingzhong Wang, Pomona, NY (US);
Rocco John Galante, Oakland, NJ (US);
Wyeth LLC, Madison, NJ (US);
Abstract
Compounds of Formula (I), are provided where T is CHO, COR, or C(OH)RR; Rand Rare hydrogen, optionally substituted lower alkyl, CF, optionally substituted alkenyl, or optionally substituted alkynyl; Ris hydrogen or optionally substituted lower alkyl; Ris (CF)alkyl, (CF)(substitutedalkyl), (CF)alkylphenyl, (CF)alkyl(substitutedphenyl), or (F)cycloalkyl; n=1-3; Ris hydrogen, halogen, CF, diene fused to Y when Y=C, or substituted diene fused to Y when Y=C; W, Y and Z are C, CRor N where at least one of W, Y or Z are C; Ris hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO, or NR; Ris hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and Ris lower alkyl, CF, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.