The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Sep. 30, 2003
Antibody tools for the diagnostic use in the medical therapy with inhibitors of histone deacetylases
Giuseppe Pier Pelicci, Opera, IT;
Saverio Minucci, Opera, IT;
Daniele Piccini, Locate de Triulzi, IT;
Marco Maccarana, Seriate, IT;
Simona Ronzoni, Mariano Comense, IT;
Beatriz Liliana Areces, Milan, IT;
Mario Faretta, Corsico, IT;
Giuseppe Pier Pelicci, Opera, IT;
Saverio Minucci, Opera, IT;
Daniele Piccini, Locate de Triulzi, IT;
Marco Maccarana, Seriate, IT;
Simona Ronzoni, Mariano Comense, IT;
Beatriz Liliana Areces, Milan, IT;
Mario Faretta, Corsico, IT;
TopoTarget Germany AG, Frankfurt am Main, DE;
Abstract
The invention relates to a method for determining whether a treatment of a disorder with an HDAC inhibitor is to be started/continued or not comprising determining the level of histone acetylation in the sample by use of an antibody capable of binding to acetylated histone, and classifying the disorder as to be treated with an HDAC inhibitor when the level of histone acetylation is significantly lower than that of a reference sample. The invention further relates to the diagnostic and prognostic use of specific antibodies and cell lines producing them.