The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
May. 07, 2004
Vera Cherepinsky, Sandy Hook, CT (US);
Bhubaneswar Mishra, Great Neck, NY (US);
Ghazala Hashmi, Holmdel, NJ (US);
Michael Seul, Fanwood, NJ (US);
Vera Cherepinsky, Sandy Hook, CT (US);
Bhubaneswar Mishra, Great Neck, NY (US);
Ghazala Hashmi, Holmdel, NJ (US);
Michael Seul, Fanwood, NJ (US);
Bioarray Solutions, Ltd., Warren, NJ (US);
Abstract
Disclosed is an analysis method useful in multiplexed hybridization-mediated analysis of polymorphisms, i.e., wherein a labeled nucleic acid of interest ('target') interacts with two or more pairs of immobilized degenerate capture probes. In one embodiment, one member of each pair has a sequence that is complementary to the normal ('wild-type') sequence in a designated location of the target, while the other member of each pair has a sequence that is complementary to an anticipated variant (“mutant” or “polymorph”) sequence in that location of the target. These methods permit selection of two or more probe pairs such that, for each pair of probes interacting with a given target strand, interaction of the target with a preferred member of the probe pair is optimized. Also interpreting results obtained by multiplexed hybridization of the target to two or more pairs of probes under conditions permitting competitive hybridization is disclosed.