The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Sep. 01, 2003
Applicants:
Mariagrazia Pizza, Siena, IT;
Vega Masignani, Siena, IT;
Inventors:
Mariagrazia Pizza, Siena, IT;
Vega Masignani, Siena, IT;
Assignee:
Novartis AC, Basel, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 39/00 (2006.01); C12N 9/22 (2006.01); C07H 21/04 (2006.01); A61K 38/00 (2006.01); A61K 38/04 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
NMB1343 is an ADP-ribosylating toxin from. The invention provides a mutant toxin having a substitution at one or more of amino Glu-109, Glu-111 or Glu-120. The mutations(s) is/are preferably Glu to Asp. The protein of the invention preferably has reduced or eliminated ADP-ribosyltransferase and/or NAD-glycohydrolase activity relative to the wild-type protein.