The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Oct. 04, 2005
David Myung, Mountain View, CA (US);
Jaan Noolandi, Palo Alto, CA (US);
Alan J. Smith, Redwood City, CA (US);
Curtis W. Frank, Cupertino, CA (US);
Christopher Ta, Saratoga, CA (US);
Yin HU, Palo Alto, CA (US);
Won-gun Koh, Seoul, KR;
Michael R. Carrasco, Sunnyvale, CA (US);
David Myung, Mountain View, CA (US);
Jaan Noolandi, Palo Alto, CA (US);
Alan J. Smith, Redwood City, CA (US);
Curtis W. Frank, Cupertino, CA (US);
Christopher Ta, Saratoga, CA (US);
Yin Hu, Palo Alto, CA (US);
Won-Gun Koh, Seoul, KR;
Michael R. Carrasco, Sunnyvale, CA (US);
The Board of Trustees of the Leland Stanford Junior Iniversity, Palo Alto, CA (US);
Santa Clara University, Santa Clara, CA (US);
Abstract
A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.