The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Aug. 31, 2007
Timothy a Mccaffrey, Silver Spring, MD (US);
Zhaoqing Yang, Arlington, VA (US);
Dmitry Gagarin, Glen Burnie, MD (US);
Timothy A McCaffrey, Silver Spring, MD (US);
Zhaoqing Yang, Arlington, VA (US);
Dmitry Gagarin, Glen Burnie, MD (US);
Other;
Abstract
The present invention relates to new use of inhibitors of bcl-2/bcl-Xl family of anti-apoptotic compounds for the treatment of post-angioplasty restenosis and in-stent restenosis. Small molecules of Bcl inhibitors are incorporated into a stent, typically by a fine polymeric coating over the metal, which would be placed during angioplasty of occluded blood vessels, to act on fibroproliferative in-growth. Hollow organs such as urethras, Fallopian tubes and vascular access grafts could be treated in a similar manner to prevent their closure due to fibrosis. Other iatrogenic fibrosis such as adhesions after surgery could also be blocked by this therapy.