The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2010
Filed:
Sep. 14, 2001
Mitsuharu Nakamura, Tokyo, JP;
Takao Kamahori, Tokyo, JP;
Seigo Ishibuchi, Tokyo, JP;
Yoichi Naka, Nakatsu, JP;
Hiroshi Sumichika, Tokyo, JP;
Katsuhiko Itoh, Saitama, JP;
Mitsuharu Nakamura, Tokyo, JP;
Takao Kamahori, Tokyo, JP;
Seigo Ishibuchi, Tokyo, JP;
Yoichi Naka, Nakatsu, JP;
Hiroshi Sumichika, Tokyo, JP;
Katsuhiko Itoh, Saitama, JP;
Mitsubishi Tanabe Pharma Corporation, Osaka-shi, JP;
Abstract
The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.