The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2010
Filed:
Dec. 30, 2005
Syed Kasmiri, North Potomac, MD (US);
Rafia Mehdi Kashmiri, Legal Representative, North Potomac, MD (US);
Jeffrey Schlom, Potomac, MD (US);
Eduardo A. Padlan, Kensington, MD (US);
Syed Kasmiri, North Potomac, MD (US);
Rafia Mehdi Kashmiri, legal representative, North Potomac, MD (US);
Jeffrey Schlom, Potomac, MD (US);
Eduardo A. Padlan, Kensington, MD (US);
Abstract
The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.