The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2010
Filed:
Feb. 08, 2006
Zemer Gitai, San Mateo, CA (US);
Lucy Shapiro, Stanford, CA (US);
Masaaki Wachi, Midori-ku, JP;
Noritaka Iwai, Midori-ku, JP;
Zemer Gitai, San Mateo, CA (US);
Lucy Shapiro, Stanford, CA (US);
Masaaki Wachi, Midori-ku, JP;
Noritaka Iwai, Midori-ku, JP;
The Board of Trustees of the Leland Stamford Junior University, Palo Alto, CA (US);
Tokyo Institute of Technology, Tokyo, JP;
Abstract
The identification of MreB as essential for bacterial chromosome segregation provides a new target for antibiotic action. The MreB function is useful in the development of screening assays for new antibiotics, which may use, for example, genetic mutants in MreB, tests of MreB mediated chromosome segregation, and the like. In one embodiment of the invention, the antibiotic is an isothiourea compound, which may comprise a polyhalogenated benzyl group, e.g. at the 4 position, the 2,4 position, etc. A pharmaceutical composition comprising an MreB targeted antibiotic as an active agent is administered to a patient suffering from a microbial infection, particularly bacterial infections.