The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 21, 2010

Filed:

Nov. 29, 2007
Applicants:

Simon Charles Goodacre, Harlow, GB;

Karen Williams, Harlow, GB;

Stephen Price, Harlow, GB;

Hazel Joan Dyke, Harlow, GB;

John Gary Montana, Harlow, GB;

Mark S. Stanley, Pacifica, CA (US);

Liang Bao, Daly City, CA (US);

Wendy Lee, San Ramon, CA (US);

Inventors:

Simon Charles Goodacre, Harlow, GB;

Karen Williams, Harlow, GB;

Stephen Price, Harlow, GB;

Hazel Joan Dyke, Harlow, GB;

John Gary Montana, Harlow, GB;

Mark S. Stanley, Pacifica, CA (US);

Liang Bao, Daly City, CA (US);

Wendy Lee, San Ramon, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/5025 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.


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