The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2010
Filed:
Aug. 22, 2008
Robert F. Garry, New Orleans, LA (US);
Srikanta Dash, New Orleans, LA (US);
David H. Coy, New Orleans, LA (US);
Jane A. Mckeating, Birmingham, GB;
Robert F. Garry, New Orleans, LA (US);
Srikanta Dash, New Orleans, LA (US);
David H. Coy, New Orleans, LA (US);
Jane A. McKeating, Birmingham, GB;
The Administrators of the Tulane Educational Fund, New Orleans, LA (US);
The Rockefeller University, New York, NY (US);
Abstract
The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.