The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2010
Filed:
Mar. 17, 2005
Peter Herold, Basel, CH;
Stefan Stutz, Basel, CH;
Robert Mah, Muttenz, CH;
Vincenzo Tschinke, Binningen, CH;
Aleksandar Stojanovic, Basel, CH;
Nathalie Jotterand, Basel, CH;
Michael Quirmbach, Basel, CH;
Dirk Behnke, Grenzach-Wyhlen, CH;
Christiane Marti, Baden, CH;
Peter Herold, Basel, CH;
Stefan Stutz, Basel, CH;
Robert Mah, Muttenz, CH;
Vincenzo Tschinke, Binningen, CH;
Aleksandar Stojanovic, Basel, CH;
Nathalie Jotterand, Basel, CH;
Michael Quirmbach, Basel, CH;
Dirk Behnke, Grenzach-Wyhlen, CH;
Christiane Marti, Baden, CH;
Novartis AG, Basel, CH;
Abstract
The application relates to novel alkanamides of the general formula (I) where X is —CH— or >CH—OH; (A) Ris e.g. an optionally substituted heterocyclyl radical or an optionally substituted polycyclic, unsaturated hydrocarbon radical where X is hydroxymethylene; Ris C-C-alkyl or C-C-cydoalkyl; Rare each independently H, C-C-alkyl, C-alkoxycarbonyl or C-C-alkanoyl; Ris C-C-alkyl, C-C-cycloalkyl, C-C-alkenyl or unsubstituted or substituted arylC-C-alkyl; Ris C-C-alkyl, C-C-hydroxyalkyl, C-C-alkoxy-C-C-alkyl, C-C-alkanoyloxy C-C-alkyl, C-C-aminoalkyl, C-C-alkylamino-C-C-alkyl, C-C-dialkylamino-C-C-alkyl, C-C-alkanoylamido-C-C-alkyl, HO(O)C—C-C-alkyl, C-C-alkyl-O—(O)C—C-C-alkyl, HN—C(O)—C-C-alkyl, C-C-alkyl-HN—C(O)—C-C-alkyl, (C,-C-alkyl)N—C(O)—C-C-alkyl, C-C-alkenyl, C-C-alkynyl, cyano-C-C-alkyl, halo-C-C-alkyl, optionally substituted aryl-C-C-alkyl, optionally substituted C-C-cycloalkyl-C-C-alkyl or optionally substituted heterocydyl-C-C-alkyl; to a process for their preparation and to the use of these compounds as medicines, especially as renin inhibitors for the treatment of hypertension.