The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2010
Filed:
Oct. 31, 2007
Euan Alexander Arnott, Macclesfield, GB;
John Crosby, Altrincham, GB;
Matthew Charles Evans, Macclesfield, GB;
James Gair Ford, Macclesfield, GB;
Martin Francis Jones, Macclesfield, GB;
Kevin William Leslie, Macclesfield, GB;
Ian Michael Mcfarlane, Macclesfield, GB;
George Joseph Sependa, Macclesfield, GB;
Euan Alexander Arnott, Macclesfield, GB;
John Crosby, Altrincham, GB;
Matthew Charles Evans, Macclesfield, GB;
James Gair Ford, Macclesfield, GB;
Martin Francis Jones, Macclesfield, GB;
Kevin William Leslie, Macclesfield, GB;
Ian Michael McFarlane, Macclesfield, GB;
George Joseph Sependa, Macclesfield, GB;
AstraZeneca AB, Sodertalje, SE;
Abstract
The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-[(4-fluoro-2-methy-1-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline starting from a compound of Formula IX: wherein Ris a protecting group; or an intermediate there between, using process steps, reagents and conditions as described.