The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2010
Filed:
Nov. 18, 2005
Yumiko Wada, Billerica, MA (US);
Rongzhen LU, Lincoln, MA (US);
Albert Y. Hsia, Cambridge, MA (US);
Synta Pharmaceuticals Corp., Lexington, MA (US);
Abstract
This invention features pyrimidine compounds of formula (I): aryl, or heteroaryl; each of Rand R, independently, is R, halogen, nitro, cyano, isothionitro, SR, or OR; or Rand R, taken together, is carbonyl; Ris R, alkenyl, alkynyl, OR, OC(O)R, SOR, S(O)R, S(O)NRR, SR, NRR, NRCOR, NRC(O)OR, NRC(O)NRR, NRSOR, COR, C(O)OR, or C(O)NRR; Ris H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O), or NR; Y is a covalent bond, CH, C(O), C═N—R, C═N—OR, C═N—SR, O, S, S(O), S(O), or NR; Z is N or CH; one of U and V is N, and the other is CR; and W is O, S, S(O), S(O), NR, or NC(O)R; in which each of Rand R, independently, is H, alkyl, aryl, heteroaryl; and each of Rand R, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl. The featured compounds inhibit the production of IL-12, IL-23 and IL-27 and are useful for treating disorders associated with IL-12, IL-23 and IL-27 overproduction or misregulation, such as inflammatory and immune disorders.