The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2010
Filed:
Dec. 27, 2006
Hiroaki Nitta, Oro Valley, AZ (US);
Thomas M. Grogan, Tucson, AZ (US);
Phillip Miller, Tucson, AZ (US);
Hiroaki Nitta, Oro Valley, AZ (US);
Thomas M. Grogan, Tucson, AZ (US);
Phillip Miller, Tucson, AZ (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Abstract
The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na, K-ATPase expression. For example, it is demonstrated herein that expression of the Na, K-ATPase β1-subunit increases in cervical dysplasia and cervical cancer, relative to normal cervical tissue. Also provided are methods of treating cervical dysplasia and cervical cancer by decreasing the biological activity of the Na, K-ATPase. For example, therapeutically effective amounts of one or more Na, K-ATPase inhibitors can be applied to the cervix to treat cervical dysplasia and cervical cancer.