The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2010
Filed:
May. 01, 2006
Victor M. Garsky, Blue Bell, PA (US);
Joseph G. Joyce, Lansdale, PA (US);
Paul M. Keller, Lansdale, PA (US);
Gene Kinney, Collegeville, PA (US);
Xiaoping Liang, Collegeville, PA (US);
John W. Shiver, Doylestown, PA (US);
Victor M. Garsky, Blue Bell, PA (US);
Joseph G. Joyce, Lansdale, PA (US);
Paul M. Keller, Lansdale, PA (US);
Gene Kinney, Collegeville, PA (US);
Xiaoping Liang, Collegeville, PA (US);
John W. Shiver, Doylestown, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The invention provides compositions and methods for the treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, such as Alzheimer's disease. Such methods entail administering an immunogenic fragment of Aβ, lacking a T-cell epitope, capable of inducing a beneficial immune response in the form of antibodies to Aβ. In another aspect, the immunogenic fragment of Aβ is capable of elevating plasma Aβ levels. The immunogenic fragments comprise linear or multivalent peptides of Aβ. Pharmaceutical compositions comprise the immunogenic fragment chemically linked to a carrier molecule which may be administered with an adjuvant.